CASA 325 GUESTHOUSE, Key West

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From$285 /night
Check-in
04Sept
Check-out
05Sept
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

325 Duval Street, Key West, 33040
-
Close to the historic old town
Perfect
9.0
9.1
/10
4.5
/5

Charming Guesthouse on Duval Street, Key West

Overview

Casa 325 Guesthouse occupies a prime location at 325 Duval Street, just steps away from local attractions, restaurants, and shops. This quaint guesthouse offers a variety of unique room types, each designed to provide a distinctive Key West experience. The guesthouse is set back from the bustling street, allowing for a retreat-like atmosphere while being close to the excitement of Old Town.

Accommodations

The guesthouse offers several room types, including cozy studios like Rosie and Lilly, which feature private baths and kitchenettes. Guests can choose from multi-bedroom suites, such as the two-bedroom poolside ADA room, which accommodates up to four people. Each unit is equipped with essential amenities such as air conditioning and kitchen facilities.

Concierge Service

The hotel provides a complimentary concierge service that assists guests with bookings for activities such as sunset cruises and fishing expeditions. Tickets and detailed information for local attractions are delivered directly to guests' rooms, saving time and effort. This service enhances the overall experience by simplifying planning during the stay.

Location

Casa 325 is conveniently located one mile from Fort Zachary Taylor State Park Beach, making it accessible for beach activities. Guests can easily walk or bike to nearby attractions like Smathers Beach and Higgs Beach. The guesthouse is situated between Eaton Street and Caroline Street, providing easy access to the local nightlife.

Additional Information

Late check-in is facilitated through a convenient process allowing guests to collect their keys from a secure mailbox. The guesthouse supports accessibility with its ADA-compliant two-bedroom suite, ensuring all guests can enjoy their stay. Casa 325 also has designated parking arrangements available nearby.

Highlights

Location: Steps from restaurants and shops on Duval Street

Accommodations: Unique rooms like Rosie and Lilly studios

Concierge Service: Free bookings for local activities

Accessibility: ADA-compliant two-bedroom suite

“The property places you right on Duval Street, perfect for experiencing Key West's lively atmosphere. This intimate guesthouse channels an old Florida vibe, complete with a hidden tiki bar and pool. Be prepared for the downtown energy, which extends into the night-but for those seeking non-stop action, it's a great choice.”
Hotel logo
Olivia SmithEditor-in-Chief at Cheaphotels

Room rates & availability calendar

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September 2026 - September 2027
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Check-in/ Check-out

Amenities & services

Real traveler stories and honest reviews—no glossy ads, just authentic feedback to guide your booking

General

  • Wi-Fi

Room features

  • Sitting area
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV

Room decor

  • Parquet floor
Show more

Casa 325 Guesthouse Location

325 Duval Street, Key West, 33040
Explore Key West
Explore Key West
  • Top Attractions
  • Activities
  • Dining
  • Entertainment
Audubon House and Tropical Gardens
Audubon House and Tropical Gardens
8 minutes walking
Historic home with exquisite gardens showcasing tropical plants and birds, ideal for nature lovers and peace seekers.
The Ernest Hemingway Home and Museum
The Ernest Hemingway Home and Museum
13 minutes walking
Famed residence of literary giant Ernest Hemingway, featuring guided tours that highlight his life and works in Key West.
Southernmost Point
Southernmost Point
13 minutes walking
Iconic buoy marking the southernmost point in the continental U.S., perfect for memorable photo opportunities.
Mallory Square
Mallory Square
8 minutes walking
Bustling waterfront square known for its sunset celebration, featuring street performers, art vendors, and local culture.
Stand-Up Paddleboarding
10 minutes driving
Exciting paddleboarding experiences available at nearby beaches, with rentals and lessons perfect for all skill levels.
Key West Butterfly and Nature Conservatory
Key West Butterfly and Nature Conservatory
13 minutes walking
A serene environment where guests can walk among exotic butterflies and lush plants, suitable for relaxation and kids.
Bull and Whistle Bar
2 minutes walking
Lively bar known for its casual atmosphere and pub fare, offering great drinks and nightly entertainment options.
Glazed Donuts
3 minutes walking
Charming donut shop featuring unique flavors and freshly made desserts, perfect for a sweet treat any time of day.
Key West Theater
6 minutes driving
A cultural hub offering live performances ranging from concerts to comedy, providing engaging entertainment for all ages.
The Green Parrot Bar
10 minutes walking
A lively bar featuring live music, a casual vibe, and a great selection of beers, perfect for nightlife enthusiasts.
Getting around town
  • City Centre
    Key West 27 min  ·  1.4 mi
  • Airports
    Key West International (EYW) 10 min  ·  4.0 mi
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Property information and rules
Check-in
from 15:00-18:00
Check-out
from 06:00-11:00
Guest Parking
No parking available.
Internet
Wireless internet is available in the entire hotel for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Number of rooms:
12

Reviews and Ratings

What past guests shared about their stay
Pros
Perfect location
Onsite parking
Clean rooms
Inviting pool
Helpful staff
Cons
Small kitchen
Steep stairs
No sink
No storage
Guest reviews
based on 179 reviews
9.0/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
FAQs
About Casa 325 Guesthouse
What is the check-in and check-out policy at Casa 325 Guesthouse?
Check-in is at 15:00 and check-out is at 11:00.
How far is Casa 325 Guesthouse from Mallory Square?
Casa 325 Guesthouse is located 0.5 km from Mallory Square.
What nearby restaurant options are available around Casa 325 Guesthouse?
Nearby restaurants include Sloppy Joe's Bar (0.5 km), The Flaming Buoy Filet Co (0.5 km), Fogarty's (0.5 km), and Grand Cafe (0.5 km).
What facilities does Casa 325 Guesthouse offer?
Facilities include free Wi-Fi, an outdoor swimming pool, and on-site parking.
What types of room amenities are available at Casa 325 Guesthouse?
Rooms feature air conditioning, flat-screen TVs, tea and coffee making equipment, and kitchenettes.
Is there a swimming pool at Casa 325 Guesthouse?
Casa 325 Guesthouse features an outdoor swimming pool that is open year-round.
What languages are spoken by the staff at Casa 325 Guesthouse?
The staff at Casa 325 Guesthouse speaks English.
How far away is the nearest beach from Casa 325 Guesthouse?
Smathers Beach and Higgs Beach, located on the Atlantic side, are approximately 2 km from Casa 325 Guesthouse.
Are there any popular attractions near Casa 325 Guesthouse?
Attractions such as Curry Mansion (0.5 km) and the Minor Basilica of Saint Mary Star of the Sea (1 km) are within walking distance.
Does Casa 325 Guesthouse offer any recreational activities?
Casa 325 Guesthouse offers bicycle rentals for guests.
What are the outdoor features at Casa 325 Guesthouse?
There is an outdoor swimming pool with plenty of lawn chairs and shaded areas.